Cells can adhere to other cells or to the extracellular matrix (ECM) by cell junctions which are subcellular macromolecular structures and regulate many important biological processes. There are several types of cell junctions including tight junctions, adherent junctions, gap junctions, focal adhesion, hemidesmosomes and desmosomes. Cell junctions play a specific role in cell adhesion and transduction of mechanical force. A lot of pathophysiology of diseases such as cancer metastasis, developmental abnormalities, cardiovascular diseases and neurological disorders appear the destabilization of cell junction integrity and function via gene expression changes or gene mutations. To detect the gene expression changes and gene mutations of cell junctions, profiler PCR array system has been applied, which combines the quantitative performance of PCR with the multiple gene profiling of microarrays.
Figure 1. The two different types of Cell Adhesion PCR Arrays
The Extracellular Matrix and Adhesion Molecules PCR Arrays are widely used to profile dozens of genes involved in cell-cell and cell-matrix adhesion simultaneously. It is useful to get meaningful data on the adhesion molecule gene expression by the adhesion molecules PCR arrays and these adhesion molecules include laminins, collagens and other basement membrane molecules. These PCR arrays also enable quick and reliable pathways analysis of adhesion molecule gene expression. This method can save much time which is spent at the bench and ensure a successful experiment every time. The application specialists in our team are available to provide the best technique support for your research. Even we can modify the PCR arrays to suit your unique needs and offer the data analysis according to your requirement.
Figure 2. The experimental results of Cell Adhesion PCR Array Assay
In summary, the Extracellular Matrix and Adhesion Molecules PCR Arrays at Creative Bioarray are powerful and convenient to study the multiple gene expression changes or gene mutations of adhesion molecules simultaneously.
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