Gamma-Secretase Activity Assay

γ-secretase is an enzyme complex that plays a key role in processing several transmembrane proteins, including the amyloid precursor protein (APP) linked to Alzheimer's disease (AD). Specifically, it cleaves the C-terminal fragment C99 in the transmembrane domain of APP. This process leads to the release of various lengths of Aβ peptides, with Aβ40 and Aβ42 being the predominant forms. By inhibiting or modulating γ-secretase, it is possible to decrease the production of Aβ peptides and alleviate their harmful effects.

Creative Bioarray's γ-secretase activity assay offers a valuable platform for screening compounds or drugs with the potential to inhibit or modulate γ-secretase activity.

Screening for γ-Secretase Inhibitors

  • Cell Line for γ-Secretase Activity Assay
    APP-C99-GFP Stable Cell Line - U2OS
  • Image Analysis - Fluorescent Quantification
  • Dose Response - Determination of IC50 Value
* For scientific research only

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