High-Throughput Screening

High-Throughput Screening (HTS) is a drug discovery technique used in the pharmaceutical industry to quickly screen large numbers of chemical compounds for potential activity against a specific target. It involves automated testing of thousands to millions of compounds in a short period to identify potential lead compounds for further development. The HTS facility supports a wide range of detection modalities for assay measurements, including absorbance, luminescence, fluorescence, fluorescence resonance energy transfer (FRET), etc.

Creative Bioarray provides HTS services to support the drug discovery and development process. With our state-of-the-art technology and expertise in assay development, we can efficiently and effectively screen large libraries of compounds to identify potential drug candidates.

In cell-based HTS, cells are cultured in multiwall plates and treated with various compounds or agents. The cells are then analyzed for specific changes, such as alterations in cell viability, proliferation, apoptosis, gene expression, etc., using optimized methods. This allows researchers to identify compounds that may have therapeutic potential or provide insight into cellular processes.

Highlights of Creative Bioarray's High-Throughput Screening

  • Rich cell line libraries, more than 500 cancer cell types and thousands of target-specific cell lines.
  • Adaptable to diverse research objectives: drug discovery, toxicology studies, functional genomics, and other testing purposes.
  • Tailor your study with adaptable template designs.

Flow Chart of High-Throughput Screening

Flow Chart of High-Throughput Screening

Diverse Screening Libraries

  • Cell Line Libraries
    • Cancer Cell-based HTS
      Enhance your compound's chances of becoming a validated candidate through our cost-effective, rapid, and large-scale cancer cell line screening. Creative Bioarray offers crucial insights into your agent's cytotoxicity and chemotherapeutic potential at an early stage of drug development.
      • Cytotoxicity Assay
  • Target-specific Cell-based HTS
    More than 1,000 functionally verified kinase, GPCR, and ion channel cell lines are used for high-throughput screening of different target drugs.
    • Kinase Assay
    • GPCR Assay
    • Ion Channel Assay
  • RNAi Libraries (Cell-based RNAi Screening)
    Creative Bioarray offers an extensive short hairpin RNA (shRNA) library consisting of over 10,000 shRNAs, effectively targeting more than 3,000 different human druggable targets. Cell-based RNAi screening using cDNA libraries is a high-throughput method that allows researchers to identify genes that are essential for a specific cellular process or disease phenotype. This approach has been widely used in basic research as well as drug discovery and target validation studies.
* For scientific research only

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