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The accidental death of cells occurs when they are damaged or subjected to physical trauma. Pyroptosis is a recently discovered pathway of host cell death. Creative Bioarray can provide customers with immunofluorescence staining services of GSDMD/GSDME to accurately identify pyroptosis.

Background

Pyroptosis is a process of programmed inflammatory cell death. Compared with apoptosis, pyroptosis occurs faster and is accompanied by the release of a large number of pro-inflammatory factors. It causes shearing and multimerization of various Gasdermin family members including GSDMD, causing cell perforation, and then cell death.

Main features of pyroptosis:

Immunofluorescence-Staining

1. Rupture of the cell membrane.

2. Random degradation of DNA.

3. The production of inflammatory bodies.

4. The release of inflammatory cytokines IL-1β and IL-18.

Our Services

Pyrocytosis is widely involved in the occurrence and development of various diseases. Therefore, the study of cell pyroptosis helps to understand its role in related diseases and provides new ideas for clinical treatment. Our services include but are not limited to:

Immunofluorescence Staining of GSDMD/GSDME

Studies have shown that GSDMD is closely related to the formation of holes in the cell membrane. Gasdermin D is composed of 480 amino acids and can be divided into two functional domains: gasdermin-N domain at the N-terminus and gasdermin-C domain at the C-terminus. The two domains are connected by a long loop.Caspase-1 and caspase-11 (caspase-4, caspase-5 in humans) can cut Gasdermin D from the loop ring, and the gasdermin-N domain can form 1-2nm pores on the cell membrane surface, thereby promoting the occurrence of pyrolysis.

Creative Bioarray can use fluorescent immunostaining to detect Gasdermin D to help you identify pyroptosis.

Customer Notice

Customers provide

  • Test samples
  • Test purpose
  • Test requirements

We deliver

  • Quality-assured test reagents
  • Experiment process and records
  • Photos and relevant analysis data
  • Complete experiment report

Experiment cycle

The time depends on the experiment content

Advantages of Our Services

  • Complete instrument platform

    We have many types of microscopes and other instruments with high resolution to provide you with clear and high-quality pictures.

  • Professional

    The research team have many years of successful experiment experience and can guarantee the standard of experiment operation and experiment process.

  • Short time and low cost

    We provide customers with the most comprehensive services at the most favorable price and help customers improve the efficiency of research.

  • Safety

    All experiments have signed confidentiality agreements, focusing on protecting customer privacy.

If you are interested in our services, please contact us for more detailed information.

* For scientific research only

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