Apoptosis is a physiologically active and spontaneous programmed cell death method, while pyroptosis is a highly inflammatory programmed cell death method. Creative Bioarray can provide customers with pyroptosis related inflammatory factors expression level detection services to make your research on pyroptosis more accurate and convenient.
Pyroptosis is a highly inflammatory cell death mode, which can accelerate the immune response to resist the invasion of pathogens and promote the elimination of pathogens.
Because of the formation of micropores in the cell membrane, pyroptosis cells lose the ability to regulate the entry and exit of substances. The osmotic balance on both sides of the cell membrane is broken, and the inflammatory factors and pro-inflammatory mediators are released.
There are two ways of pyroptosis:
Both of these pathways can cause severe inflammation, and IL-1β and IL-18 play an important role in this process. IL-1β can recruit and activate other immune cells, and induce the synthesis of chemokines (such as IL-18), inflammatory factors (such as IL-6), and adhesion molecules. Eventually, the "waterfall benefit" and "cascade effect" are formed, which amplify the inflammatory response and lead to the occurrence of severe inflammation.
Inflammation is a typical feature of pyroptosis. Our services include but are not limited to:
Creative Bioarray uses Western blotting or ELISA to help you detect the levels of a series of inflammatory factors related to pyrolysis, including but not limited to IL-1β, IL-18, IL-6, etc.
The time depends on the experiment content
If you are interested in our services, please contact us for more detailed information.