Parkin is a protein associated with Parkinson's Disease (PD) and plays a crucial role in the process of mitophagy. Mitophagy is the selective removal of damaged or dysfunctional mitochondria, a process essential for maintaining cellular health. In PD, mutations in the PARK2 gene, which encodes Parkin, are linked to autosomal recessive forms of the disease.
Parkin's role in mitophagy involves its recruitment to damaged mitochondria, marking them for degradation. This process of Parkin-mediated mitophagy helps maintain mitochondrial quality control and cellular homeostasis. In Parkinson's Disease, mutations in the PARK2 gene can disrupt Parkin function, impairing its ability to ubiquitinate damaged mitochondria and initiate mitophagy.
Creative Bioarray's modified cell lines are a highly efficient tool for discovering compounds that can enhance the mitochondrial localization of Parkin without causing significant mitochondrial damage.