Parkinson's disease (PD) is a slowly progressive neurodegenerative disease characterized clinically by progressive movement disorders. With loss of dopaminergic neurons within the substantia nigra, synaptic and axonal degeneration leads to reduced dopamine levels within the nigrostriatal circuit. This leads to a motor dysfunction and the development of the classical symptoms of PD such as bradykinesia, resting tremors and rigidity. In addition to the loss of dopaminergic neurons, the intracellular formation of Lewy bodies, mainly composed of aggregated α-synuclein, has been implicated in the pathogenesis of the disease.
Creative Bioarray offers various in vitro cellular models that play a crucial role in helping researchers study the pathogenesis of Parkinson's disease (PD) and conduct preclinical testing for potential therapies. These in vitro cellular models are suitable for evaluation of neuroprotective compounds for PD treatment, in particular via high throughput screening approaches.