Cardiovascular diseases (CVDs) are a group of disorders that affect the heart and blood vessels, often leading to conditions that impair blood circulation, heart function, and overall cardiovascular health. The goal of many investigators is to develop suitable and robust in vitro cellular models that recapitulation human cardiovascular disease in order to trace pathologic phenotypes, elucidate molecular mechanisms, and discover therapeutics with simple and reproducible techniques.
Figure 1. Modeling cardiac diseases with patient-specific induced pluripotent stem cells (iPSC). [1]
In addition to the cardiovascular and non-cardiovascular primary cells and embryonic stem cells, induced pluripotent stem cells (iPSCs) and their differentiation potential for large-scale cardiovascular experiment brings new prospects. Creative Bioarray has significant expertise in drug discovery in the field of cardiovascular diseases. Our biological scientists are adept at developing in vitro cellular models for individual projects to meet customers' drug discovery needs.
Advantages of Human iPSC-derived Cardiomyocytes (hiPSC-CMs):
Reference:
1. Sinnecker, Daniel et al. "Induced pluripotent stem cell-derived cardiomyocytes: a versatile tool for arrhythmia research." Circulation research vol. 112,6 (2013): 961-8. doi:10.1161/CIRCRESAHA.112.268623
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