Alpha-synuclein (α-synuclein) is a protein that plays a significant role in Parkinson's Disease (PD), a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the brain. In Parkinson's, α-synuclein undergoes abnormal changes in its structure and aggregates. These aggregates form insoluble fibrils and clumps within neurons, leading to the formation of Lewy bodies. Lewy bodies are characteristic pathological hallmarks of PD.
Creative Bioarray's α-synuclein aggregation assay provides a valuable platform for screening inhibitors with potential to modulate α-synuclein aggregation.