Alzheimer's Disease (AD) is a progressive and neurodegenerative disorder that primarily affects the brain, leading to a gradual decline in memory, cognitive abilities, and behavior. It is the most common cause of dementia, accounting for around 60-80% of all dementia cases. AD typically starts with mild memory loss and confusion, which worsens over time and eventually impairs the affected person's ability to carry out daily tasks. The two main pathological hallmarks of AD are the accumulation of abnormal protein deposits in the brain: amyloid-beta (Aβ) plaques and tau tangles. These pathological deposits in the brain are thought to be the main causes of the observed progressive cognitive decline in AD patients.
Creative Bioarray offers various in vitro cellular models that play a crucial role in helping researchers study the pathogenesis of Alzheimer's Disease (AD) and conduct preclinical testing for potential therapies. These in vitro models provide a controlled environment to study specific aspects of AD, allowing researchers to investigate disease mechanisms, test hypotheses, and screen potential drug candidates before moving to more complex and expensive in vivo studies.