Type 2 Diabetes (T2D) Cellular Model

Type 2 diabetes (T2D) is a chronic metabolic disorder characterized by insulin resistance and dysfunction of pancreatic beta cells, resulting in elevated blood glucose levels. To better understand the cellular mechanisms underlying T2D and identify potential targets for therapeutic intervention, researchers have developed cellular models of T2D using various cell types, including pancreatic beta cells, liver cells, and adipocytes.

Figure 1. Comparing healthy and type 2 diabetic phenotypes.^[1]

The Type 2 Diabetes (T2D) cellular model provided by Creative Bioarray is a valuable tool for researchers studying the pathogenesis and potential treatments for T2D. Our T2D cellular model can be used to investigate the underlying mechanisms of T2D, screen potential drug candidates, and develop personalized therapies.

Cell Culture Models

• Pancreatic Beta Cells: Insulin-secreting beta cells can be cultured to study insulin secretion, beta cell function, and the impact of various factors on these cells.
• Adipocytes (Fat Cells): Adipose tissue dysfunction is associated with T2D. Adipocytes can be cultured to investigate the role of adipose tissue in insulin resistance and inflammation.
• Hepatocytes (Liver Cells): Liver plays a key role in glucose metabolism. Cultured hepatocytes can be used to study hepatic glucose production and the effects of insulin resistance.

Assessment of Treatment

• Determination of insulin release after in vitro stimulation
• Determination of glucose level
• Determination of cytokines release (typically TNFα, IFNγ, IL10, IL4…)

Reference:

1. Reed, Josh et al. "A Review of Current Trends with Type 2 Diabetes Epidemiology, Aetiology, Pathogenesis, Treatments and Future Perspectives." Diabetes, metabolic syndrome and obesity: targets and therapy vol. 14 3567-3602. 10 Aug. 2021, doi:10.2147/DMSO.S319895