Parkinson's Disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the brain. In research, neurotoxins like 6-OHDA and MPP+ are commonly used to induce PD-like symptoms in cellular and animal models.
6-OHDA is a synthetic compound that selectively destroys dopaminergic neurons. It does this by generating reactive oxygen species (ROS) and causing oxidative stress, ultimately leading to neuronal death.
MPP+ is a metabolite of MPTP, which is converted in the brain to MPP+. MPP+ is highly toxic to dopaminergic neurons and interferes with mitochondrial function, leading to oxidative stress and neuronal death.
Creative Bioarray provides this toxic induced PD cellular models for screening potential drug candidates aimed at mitigating the toxic effects of 6-OHDA or MPP+.