Pyroptosis, also known as inflammatory necrosis, is a kind of programmed cell death. The main feature is that the cells continue to swell until the cell membrane ruptures, resulting in the release of cell contents and activating a strong inflammatory response.
Studies have shown that pyroptosis is widely involved in the occurrence and development of infectious diseases, nervous system-related diseases and atherosclerotic diseases.
The in-depth study of pyroptosis will help to understand its role in the occurrence, development and outcome of related diseases, and provide new ideas for clinical prevention and treatment.
The morphological characteristics, occurrence and regulation mechanism of pyroptosis are different from other cell death methods such as apoptosis and necrosis. Pyroptosis is programmed cell necrosis mediated by gasdermin D (GSDMD). Once this happens, the N-terminus of the GSDMD protein polymerizes and binds to lipids, forming holes in the cell membrane. The cells gradually swell until the cells rupture, and finally a large amount of cell content such as IL-1β is released, which activates a strong inflammatory response.
There are many methods for detecting pyroptosis:
|Detect morphological changes|
|Detection of pyrolysis-related proteins|
Creative Bioarray provides you with a variety of pyroptosis detection methods.
Creative Bioarray has a professional testing platform and an experienced scientific research team. We can provide scientific researchers with one-stop detection services of pyroptosis.
|Experiment content||Delivery content||Experiment cycle|
|Detection of the Expression Level of Pyroptosis -related Genes or Proteins||Pictures, raw data and experimental report||The time depends on the experiment content|
|Pyroptosis Related Inflammatory Factors Expression Level Detection||Raw data and experimental report|
|Immunofluorescence Staining of GSDMD/GSDME||Pictures and experimental report|
We promise to provide objective and unbiased experimental results, but due to the uncertainty of scientific experimental results, we do not make any commitments as to whether the experimental results meet expectations.
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