Several different types of cell death, such as autophagy, apoptosis, pyroptosis, necroptosis and ferroptosis, that can occur in cancer cells under various conditions. Each of these processes represents a distinct way in which cells can die, often with specific molecular mechanisms and implications.
Figure 1. The timeline of various cell deaths [1]
It's important to note that in cancer, the balance between these different types of cell death can be complex and context-dependent. Understanding these processes and their interplay is critical for developing targeted therapies and interventions. Researchers and clinicians aim to manipulate these cell death pathways to either promote cancer cell death or inhibit cell death in normal cells, depending on the therapeutic goal. However, achieving such manipulation requires a deep understanding of the intricate molecular mechanisms underlying these processes.
Creative Bioarray provides services for investigating diverse cancer cell death types in vitro. Our comprehensive platform empowers researchers to examine how different treatments or conditions affect various cell death pathways in cancer cells.
Reference:
1. Wang H, Zhou X, Li C, et al. The emerging role of pyroptosis in pediatric cancers: from mechanism to therapy. J Hematol Oncol. 2022;15(1):140. Published 2022 Oct 8. doi:10.1186/s13045-022-01365-6
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