DNA fragmentation is the separation or breaking of DNA strands into pieces. A distinctive feature of apoptosis is the degradation of cell chromosomal DNA, which is a common phenomenon. Chromatin DNA during apoptosis is broken into short fragments by activated endonucleases and is located in the margin of nuclei. This degradation is very specific and regular, and the resulting DNA fragments of different lengths are approximately an integral multiple of 180-200bp. This controlled degradation of DNA results from an endogenous endonuclease, which cuts chromosomal DNA at the junction of nucleosomes. This degradation is manifested in agarose gel electrophoresis, showing a specific ladder-like pattern , while necrosis is a diffuse continuous pattern.
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|DNAse I Activity Assay Kit (Fluorometric)
|Deoxyribonuclease-2-alpha (DNase II alpha) (Human) ELISA Kit
|Deoxyribonuclease-1 (DNase1) (Human) ELISA Kit
|Quick Apoptotic DNA Ladder Detection Kit
|Apoptotic DNA Ladder Isolation Kit
|Enhanced Apoptotic DNA Ladder Detection Kit
|ApoBrdU-IHC DNA Fragmentation Assay Kit
|ApoBrdU Red DNA Fragmentation Kit
|ApoBrdU DNA Fragmentation Assay Kit
|ApoDIRECT DNA Fragmentation Assay Kit