DNA Fragmentation

DNA fragmentation is the separation or breaking of DNA strands into pieces. A distinctive feature of apoptosis is the degradation of cell chromosomal DNA, which is a common phenomenon. Chromatin DNA during apoptosis is broken into short fragments by activated endonucleases and is located in the margin of nuclei. This degradation is very specific and regular, and the resulting DNA fragments of different lengths are approximately an integral multiple of 180-200bp. This controlled degradation of DNA results from an endogenous endonuclease, which cuts chromosomal DNA at the junction of nucleosomes. This degradation is manifested in agarose gel electrophoresis, showing a specific ladder-like pattern , while necrosis is a diffuse continuous pattern.

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Product Number Product Name Price
CDAP-317 DNAse I Activity Assay Kit (Fluorometric) Inquiry
CDAP-318 Deoxyribonuclease-2-alpha (DNase II alpha) (Human) ELISA Kit Inquiry
CDAP-319 Deoxyribonuclease-1 (DNase1) (Human) ELISA Kit Inquiry
CDAP-320 Quick Apoptotic DNA Ladder Detection Kit Inquiry
CDAP-321 Apoptotic DNA Ladder Isolation Kit Inquiry
CDAP-322 Enhanced Apoptotic DNA Ladder Detection Kit Inquiry
CDAP-323 ApoBrdU-IHC DNA Fragmentation Assay Kit Inquiry
CDAP-324 ApoBrdU Red DNA Fragmentation Kit Inquiry
CDAP-325 ApoBrdU DNA Fragmentation Assay Kit Inquiry
CDAP-326 ApoDIRECT DNA Fragmentation Assay Kit Inquiry
* For scientific research only