Ferroptosis is a new type of cell death discovered in recent years. It is oxidative cell death induced by small molecular substances, which is iron-dependent. Its occurrence is caused by the imbalance between the production and degradation of lipid reactive oxygen species (ROS) in cells.
At present, we have a partial understanding of its morphology, biology, and mechanism pathways, but the process of ferroptosis involves multiple mechanisms and is precisely regulated by signal pathways.
Therefore, further in-depth study of the mechanism of ferroptosis and its role in different types of diseases are of great significance for finding therapeutic targets for related diseases and the development of targeted drugs.
The commonly used detection indicators for iron-dependent cell death are summarized as follows:
|Morphology||Observing cell morphology using transmission electron microscopy|
|Cell level||Iron level detection|
Active oxygen detection
Mitochondrial membrane potential
|Molecular level||Iron death related genes and protein expression (qPCR, WB)|
|Subcellular level||Mitochondrial morphology observation|
The client needs to provide a preliminary experimental plan and provide relevant background information. Creative Bioarray can assist you in completing the design of the overall protocol. Our iron death detection services include but are not limited to:
Relying on a professional testing platform and an experienced scientific research team, Creative Bioarray can provide a variety of ferroptosis detection methods and customized ferroptosis detection services for the scientific researchers.
|Experiment content||Delivery content||Experiment cycle|
|Intracellular Iron Level Detection||Pictures and experimental report||The time depends on the experiment content|
|Active Oxygen Level Detection||Pictures and experimental report|
|Detection of Ferroptosis Related Genes and Protein Expression||Relevant data and experimental report|
|Ferroptosis-Related Mitochondria Detection||Pictures, relevant data and experimental report|
We promise to provide objective and fair experimental results, but due to the uncertainty of scientific experimental results, we do not make any commitments as to whether the experimental results meet expectations.
If you are interested in our services, please contact us for more detailed information.