Pyroptosisis a way of programmed cell death and the natural immune response of organisms. Creative Bioarraycanprovide customers with GSDMD/GSDME immunofluorescence staining services to better study pyroptosis.
Pyroptosisis a process of programmed inflammatory cell death. The cells continue to swell until the cell membrane ruptures, releasing a large amount of pro-inflammatory factors to stimulate other immune cells to resist infection and cause tissue inflammation. Pyroptosisusually occurs faster than apoptosis.
The mechanism of Pyroptosis (Lieselotte Vande Walle, et al. 2016)
When cells are subjected to different stimuli, they initiate the pyroptosis process through different pathways, and are widely involved in the occurrence and development of diseases. Our services include but are not limited to:
Pyrolysis can be divided into two main steps.
Inflammasome recognizes extracellular bacteria, viruses, drugs and other stimuli, and promotes transcription and synthesis of pro-IL1β, Nlrp3, and caspase-11 (caspase-4, caspase-5 in human).
This step is divided into the caspase-1-dependent pathway and caspase-1-independent pathway (caspase4, 5, 11 dependent pathway).
Creative Bioarray uses PCR or Western Blot to help you detect the expression level of pyrolysis-related genes or proteins, such as caspase-1\4\5\11, GSDMD, etc.
The time depends on the experiment content
If you are interested in our services, please contact us for more detailed information.