Bcl-2 is the most important regulatory protein in the apoptotic protein family. They are mainly located on the cytoplasmic surface of the nuclear membrane, the endoplasmic reticulum and the outer mitochondrial membrane. Its combination with the membrane is extremely important for its function. The Bcl-2 protein family is composed of Bcl-2, Bax, Bad, Bak and so on. The function of Bcl-2 is regulated by its protein products Bax and Bcl-xl. They usually exist and function in the form of dimers. Among them, Bcl-2 and Bcl-xl have the function of inhibiting cell apoptosis, and Bal-xs, Bad, Bax, Bak, Bik and Bid promote cell apoptosis.
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