Parthanatos Detection

Cells die by a variety of mechanisms. Terminally differentiated cells die in a variety of disorders, in part, via parthanatos, a process dependent on the activity of poly (ADP-ribose)-polymerase (PARP). Creative Bioarray provides parthanatos detection services to make your research more accurate and convenient.

Background

Parthanatos, also known as PARP-1 dependent cell death, is a new form of programmed cell death activated by PARP-1 based on DNA damage. When DNA damage chemicals or by-products of oxidative stress in the environment damage DNA, PARP-1 is over-activated, causing PAR products to accumulate. This further causes AIF to be released from the mitochondria, carries MIF to the nucleus, and finally cuts the chromosomal DNA to induce cell death.

This cell death is widely present in different organs and different diseases, including ischemia-reperfusion injury, glutamate neurotoxicity, Parkinson's disease, Alzheimer's disease, multiple sclerosis, Huntington's disease, heart disease, diabetes and inflammatory diseases.

Our Services

Parthanatos is a unique, caspase-independent, cell-death pathway that is distinct from apoptosis, necrosis or other identified forms of cell death. Our services include but are not limited to:

Parthanatos-related Markers Detection Service

Features of Parthanatos

  • PARP-1 activation produces a large amount of PAR (poly(ADP-ribose)).
  • AIF is released from mitochondria to the nucleus.
  • Chromatin condensation, resulting in a large number of fragments of DNA (20-50 kb).
  • Does not depend on caspase. Caspase inhibitors cannot prevent parthanatos.
  • PARP inhibitors and PARP-1 silencing or knockout can prevent parthanatos cell death.

The mechanism of ParthanatosThe mechanism of Parthanatos(Fatokun AA et al. 2014)

We provide services for detecting regulatory factors in parthanatos-related pathways, such as the detection of PPAR, AIF and other related markers, including but not limited to WB, PCR and other commonly used experimental methods.

In addition, it has been found that many human diseases are closely related to Parthanatos. We can help you screen your targets. By controlling the potential target sites of PARP-1, PAR and AIF, you not only can inhibit parthanatos but also control the deterioration of related diseases.

Customer Notice

Customers provide

  • Pre-experiment and formal experimental samples
  • Research purpose and requirements
  • Related background materials

We deliver

  • High-quality test reagents
  • Experiment programs and records
  • Analysis data
  • Complete experiment report

Experiment cycle

The time depends on the experiment content

Advantages of Our Services

  • Customized service

    We can help you customize a scientific experimental program according to your research purpose and requirements.

  • Professional

    The professional research team can ensure the standard of experimental operation and experimental process, and advanced instruments can ensure the accuracy and reliability of the results.

    Short time and low cost

  • We provide customers with the most comprehensive services at the most favorable price and help customers improve the efficiency of research.

  • Safety

    All experiments have signed confidentiality agreements, focusing on protecting customer privacy.

If you are interested in our services, please contact us for more detailed information.

Reference:

  1. Fatokun AA, Dawson VL, Dawson TM. (2014). Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities. British journal of pharmacology, 171(8), 2000–2016.
* For scientific research only