Caspases (cysteine-aspartic proteases) are a family of protease enzymes playing essential roles in programmed cell death.During the initiation and execution of apoptosis, the caspase enzyme is processed from an inactive zymogen to an active protease. Creative Bioarray can provide a variety of Caspases products and measurement methods to facilitate your research.
There are two main ways of apoptosis:
There are basically two mechanisms for Caspase activation, namely homo-activation and hetero-activation.Caspases involved in inducing apoptosis can be divided into two categories according to the activation mechanism: initiator and effector, which play a role in the upstream and downstream of death signal transduction, respectively. Homo-activation caspase is also called initiator caspase, including caspase-8/9/10.Hetero-activation is the activation of another caspase by one caspase, which is the classic way for the proenzyme of apoptotic protease to be activated. The caspase of hetero-activation is also called executioner caspase, including Caspase 3/6/7.
We can establish customized research programs and provide a variety of analysis techniques based on customers' requests. Our services include but are not limited to:
Creative Bioarray can help detect almost all caspase initiators and caspase executioners involved in apoptosis. We have a wide variety of caspases detection techniques for you to choose from. Caspase families can be detected by Western blotting, IF, IHC or flow cytometry as an indicator of apoptosis. Caspase activity and caspase substrates such as spliced PARP can also be measured usingsimilar methods.
The time depends on the experiment content
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