Cytotoxicity assays are designed to evaluate the impact of specific drug compounds on the viability of healthy cells within an organism. These compounds may induce either accidental cell death (necrosis) or programmed cell death (apoptosis). Throughout the nonclinical and clinical research stages of drug discovery and development, cytotoxicity assays play a crucial role in assessing the safety profile of drug candidates. This method proves invaluable in pinpointing any off-target effects that certain drug compounds may have on the human body.

In cancer treatment drug development, cytotoxicity assays play a pivotal role in various testing activities. Compounds capable of impeding or halting cell proliferation emerge as potent anti-cancer candidates.

Multiple cytotoxicity assays are employed to evaluate diverse cell functions, including cell membrane permeability, enzyme activity, ATP production, cell adherence, nucleotide uptake, and co-enzyme production. The selection of a cytotoxicity assay should be tailored to the specific drug compound, considering the intricacies of cellular function.

Creative Bioarray offers specialized in vitro 2D/3D cytotoxicity assay services, providing comprehensive insights into the impact of various compounds on cell viability.

Cell Models for Detection of Cytotoxicity

  • in vitro 2D Cytotoxicity Assay

in vitro 2D Cytotoxicity Assay

  • in vitro 3D Cytotoxicity Assay

in vitro 3D Cytotoxicity Assay

Methods for Detection of Cytotoxicity

  • MTT Assay
  • LDH Release Assay
  • Caspase 3/7 Activity Assays
* For scientific research only

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