Cell necrosis usually refers to cell death caused by accidental damage such as chemical factors (strong acid, strong base, toxic substances, etc.), physical factors (high heat, radiation, etc.), biological factors (pathogens, etc.) or pathological stimuli.
The membrane permeability of necrotic cells is increased, causing the cells to swell, and the organelles are deformed or enlarged. There is no obvious morphological change in the nucleus in the early stage, and the cell ruptures at the end to release the contents, causing inflammation in the surrounding tissues.
Many from academia have long believed that cell necrosis is a passive process. However, recent studies have also suggested that some proteins are involved in the signal regulation of cell necrosis. These studies show that cell necrosis is also programmed, so it is also called necroptosis.
Cell necrosis is an important body response to external pathological stimuli. Cells eliminate the influence of pathological stimuli on the body through their own death and inflammation, but they may also induce related diseases.
Unlike apoptosis, chromatin does not agglutinate during cell necrosis, and does not produce 200bp DNA degradation fragments, but degrades randomly without the formation of apoptotic bodies.
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