iPSCs are generated by reprogramming adult cells (e.g., skin cells) to a pluripotent state, allowing them to differentiate into any cell type, including dopaminergic neurons. iPSC-derived neurons can provide a more human-relevant model for studying Parkinson's Disease (PD).
By generating human neurons from both Parkinson's Disease (PD) patient-derived iPSCs and normal iPSCs engineered to carry risk-associated PD genetic mutations, Creative Bioarray's iPSC models are invaluable tools for investigating the mechanisms underlying PD progression.
Figure 1. Induced pluripotent stem
cells (iPSC) are obtained by transforming mature human cells (usually fibroblasts) with four genes—Oct4, Sox2, Klf4 and c-Myc. Once generated, these cells
can undergo differentiation to acquire a dopaminergic phenotype. [1]
Reference:
1. Lopes, F. M., et al. Mimicking Parkinson's Disease in a Dish: Merits and Pitfalls of the Most Commonly used Dopaminergic In Vitro Models. Neuromolecular Med. 2017, 19(2-3): 241-255.
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