iPSCs are generated by reprogramming adult cells (e.g., skin cells) to a pluripotent state, allowing them to differentiate into any cell type, including dopaminergic neurons. iPSC-derived neurons can provide a more human-relevant model for studying Parkinson's Disease (PD).

By generating human neurons from both Parkinson's Disease (PD) patient-derived iPSCs and normal iPSCs engineered to carry risk-associated PD genetic mutations, Creative Bioarray's iPSC models are invaluable tools for investigating the mechanisms underlying PD progression.

iPSC-Derived PD ModelsFigure 1. Induced pluripotent stem cells (iPSC) are obtained by transforming mature human cells (usually fibroblasts) with four genes—Oct4, Sox2, Klf4 and c-Myc. Once generated, these cells can undergo differentiation to acquire a dopaminergic phenotype. [1]


1. Lopes, F. M., et al. Mimicking Parkinson's Disease in a Dish: Merits and Pitfalls of the Most Commonly used Dopaminergic In Vitro Models. Neuromolecular Med. 2017, 19(2-3): 241-255.

* For scientific research only

Online Inquiry