Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by the progressive degeneration of motor neurons, leading to muscle weakness and atrophy. Developing in vitro co-culture models that mimic the interactions between motor neurons and muscle cells is crucial for studying ALS and testing potential therapeutic interventions. Motor neurons and muscle fibers have a mutually dependent relationship, crucial for motor unit formation and maintenance. This dependency relies on continuous trophic, electrical, and mechanical cross-talk between muscle and motor nerve.
Creative Bioarray's neuromuscular co-culture ALS models provide a platform to observe motor neuron-dependent myocontraction. This allows us to assess the potential of compounds to enhance the functionality of motor neurons.
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