Neurotoxicity Solutions

Introduction

The nervous system is very sensitive to many toxic compounds and harmful substances produced in the natural environment. In the course of the disease, neurotoxicity can cause temporary or continuous damage to the brain or peripheral nervous system. At the same time, neurotoxicity is also the main cause of many neurodegenerative diseases such as Alzheimer's and Parkinson's.

Solutions for You

In the process of drug discovery and development, neurotoxicity is a non-negligible cause of failure. Most drugs have neurotoxic effects mediated mainly by several dopaminergic and glutamatergic neurotransmitter systems. Although many researchers have investigated the medical and cognitive consequences of drug abuse, the neurotoxicity caused by these drugs still requires full attention. Creative Bioarray offers a one-stop-solution for neurotoxicity screening.

Neurotoxicity screening

The content of basic neurotoxicity screening should include specific histopathological examination and systematic clinical evaluation.

Specific histopathological examination Specific histopathological examination of tissue samples representing all major areas and elements of the brain, spinal cord and peripheral nervous system.

Systematic clinical evaluation Systematic clinical evaluation of laboratory animals uses a clearly defined series of clinical tests and observations. These experiments and observations were selected to detect major neurological diseases, behavioral abnormalities, physical dysfunction and any other signs of neurotoxicity.

Effect characterization

Neurotoxicity test After screening a chemical substance that has an adverse effect on the nervous system, the next stage of testing focuses on determining the chemical substance's effect on the nervous system and its properties (characterization). At this level, the neurotoxic effects found in the screening process will be further characterized, and research will be conducted to determine whether the test chemical has any other possible subtler effects on the structural and functional integrity of the nervous system of mature and developing organisms. The in-depth assessment of neurotoxicity during this testing phase should include: The nature and severity of the effect. Information on the time pattern of the onset of the effect (especially when delayed neurotoxicity occurs) and the duration of the effect. More detailed histopathological examination (including the use of special stains to highlight related nerve structures).

Response Relationships The no-observed-adverse-effect level (NOAEL) is a key element in defining the neurotoxic hazard of chemicals. In order to determine the NOAEL more quantitatively, the most relevant and sensitive endpoints are usually used for research.

In vitro models for neurotoxicology studies

Primary cells: neurons and glia (microglia, oligodendrocyte, astrocyte) from different brain regions

Cell lines: neuroblastoma, astrocytoma, glioma, pheochromocytoma

Brain slices: hippocampus

Reaggregating neuronal and glial cell cultures

Organotypic (3D) cultures; usually co-cultures (more than one type of cell)

Neural stem (progenitor) cells: primary cell cultures and cell lines

Induced pluripotent stem cell（iPSC）

Project Process

Creative Bioarray offers a series of techniques to detect neurotoxicity and reliably screen your early-stage drug candidates, before moving to costly animal models studies and avoid late-stage drug attrition. We provide stage-specific phenotype assays in our neurotoxicity platform.

Why Choose Us

Professional Platform and Excellent Team

We have a professional technical platform, equipped with advanced instruments and talented and well-trained experts.

Committed to Quality

We put quality first. We provide high-quality products, services and solutions to support customers worldwide.

World-class Service Capabilities

We provide one-stop service, from order to final report, to provide the best solution for your research. We hope to help you complete your research more easily and efficiently.

Customer-centric

We adhere to a mutually beneficial and win-win cooperation model, pay attention to customer needs and goals, and create the greatest value for customers.

If you are interested in our services, please contact us for more detailed information.