Pyroptosis is an important natural immune response of the body, which plays an important role in antagonizing infection and endogenous danger signals. Pyroptosis is essentially cell inflammatory necrosis mediated by GSDMD (gasdermin D) protein, which is closely related to a variety of pathophysiological processes.

pathophysiological processes

Due to the formation of micropores in the cell membrane, the pyroptosis cells will lose the ability to regulate the entry and exit of substances. The osmotic balance on both sides of the cell membrane is broken, resulting in the release of IL-1β, IL-18 and other inflammatory factors and pro-inflammatory mediators. Eventually, the cells burst and dissolve. The cytoplasmic content is released to the exterior environment, and more inflammatory cells are recruited due to pro-inflammatory signals to neighboring cells, which triggers an obvious inflammatory response. There will be slight DNA damage and chromosome condensation, but the nucleus remains intact.

Pyrocytosis is widely involved in the occurrence and development of infectious diseases, nervous system-related diseases and atherosclerotic diseases. The in-depth study of pyroptosis helps to understand its role in related diseases and provides new ideas for clinical prevention and treatment.

Solutions for You

Creative Bioarray has a professional pyroptosis research platform. The main methods of pyroptosis detection include but are not limited to:

Morphological Observation

  • Scanning electron microscope to observe cell morphology
  • TUNEL staining
  • Immunofluorescence staining (GSDMD/GSDME)

Detection of Pyroptosis - Related Protein

  • qPCR/Western Blot method to detect the expression level of pyroptosis-related genes or proteins
  • ELISA kit to detect the level of IL-1β, IL-18 and other inflammatory factors
  • MTT method to measure cell viability

Project Process

Creative Bioarray' professional research team has been engaged in cell death research for many years, and can provide you with professional cell pyroptosis solutions.

Project Process

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