Liver Toxicity Solutions

Introduction

The liver plays a vital role in transforming and removing chemicals in the body. It is also a common target tissue for various toxic substances, because its structure and function make the liver highly sensitive to heterologous organisms. Overdosing certain drugs and chemicals, or sometimes taking them within a therapeutic dose range, liver cell damage could occur. Importantly, more than 900 drugs have been reported to cause liver damage. In addition, drug-induced liver injury (DILI) is also one of the main reasons for drug withdrawal after marketing. Therefore, it is critical to determine the potential liver toxicity of chemicals in the early stages of development before the IND-enabling studies.

Solutions for You

Creative Bioarray has developed a variety of liver toxicity determination methods for customers. With rich experience and advanced technology, we are able to provide in vitro cell-based toxicity tests to imitate in vivo tissue studies and conduct safety assessments in the early stages of drug development. Creative Bioarray currently provides liver toxicity assessment programs including but not limited to:

In silico models QSAR/Molecular descriptors Structural alert

2D in vitro cell models HepG2 Co-cultured with human hepatocytes, stromal cells In vitro cell-free assays

3D liver toxicity model 14 Day Hepatotoxicity Testing Cross-species Hepatotoxicity Testing DILI Evaluation Service

Acute liver failure

CYP assay

Project Process

Creative Bioarray can provide global customers with various toxicology assessment services, including liver toxicity evaluations. We are committed to providing customers with one-stop service in a fast and cost-effective manner. We use the most advanced technologies to bring you the best quality services.

Why Choose Us

Professional Platform and Excellent Team

We have a professional technical platform, equipped with advanced instruments and talented and well-trained experts.

Committed to Quality

We put quality first. We provide high-quality products, services and solutions to support customers worldwide.

World-class Service Capabilities

We provide one-stop service, from order to final report, to provide the best solution for your research. We hope to help you complete your research more easily and efficiently.

Customer-centric

We adhere to a mutually beneficial and win-win cooperation model, pay attention to customer needs and goals, and create the greatest value for customers.

If you are interested in our services, please contact us for more detailed information.