P53 is a collective name for a series of homologous proteins called tumor suppressor proteins. As a typical tumor suppressor gene, the p53 gene product is a transcription factor, including wild-type and mutant forms. p53 can stimulate a wide range of signals that work through exogenous and endogenous apoptotic pathways. The exogenous pathway involves the activation of "death" receptors, thereby activating the caspase that induces apoptosis. The endogenous apoptotic pathway is regulated by Bcl-2 family proteins, which can also trigger cell death through the commonly used caspase cascade. We provide high-quality and competitively-priced P53-related research products. Contact us for a quote today.
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