Caspase-1 Antibody

Product Category:

Apoptosis Inducers & Inhibitors

Description

ONC-201 is an orally active transcriptional inducer of Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL). It induces TRAIL in a p53-independent manner at concentrations of 1.25 μM-5 μM and crosses the blood-brain barrier. It inactivates kinases Akt and extracellular signal–regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. It causes tumor regression in HCT116 p53−/− xenograft bearing mice.

Product Information

Product Number

CDAP-012

Product Name

ONC-201

cas

1616632-77-9

Similar Name

11-benzyl-7-[(2-methylphenyl)methyl]-2,5,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-one; 7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5(4H)-one; 2,4,6,7,8,9-hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)-imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one; TIC10; TRAIL-inducing compound 10

Storage Conditions

-20ºC

Molecular Weight

386.49

Appearance

White to off-white powder

Solubility

~20 mg/ml in DMF, ~10 mg/ml in ethanol, ~1 mg/ml in DMSO

MDL Number

MFCD28118993

Shipping Conditions

Purity

≥98%

Molecular Formula

C24H26N4O

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