Caspase-1 Antibody
Product Category:
Apoptosis Inducers & Inhibitors
Description
JTE-607 is a multiple cytokine inhibitor. It inhibits cytokine production specifically in human peripheral blood mononuclear cells without causing immunosuppression. It inhibits tumor necrosis factor-α (TNF-α), interleukins IL-1β, IL-6, IL-8 and IL-10 from LPS-stimulated human PBMCs with IC₅₀ values of 11 nM, 5.9 nM, 8.8 nM, 7.3 nM and 9.1 nM, respectively. It (0.4-0.8 μM) also inhibits the growth of acute myelogenous leukemia cell lines by inducing apoptosis and cell-cycle arrest.
Product Information
Product Name
JTE-607 dihydrochloride
Similar Name
ethyl (2S)-2-[[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]amino]-3-phenylpropanoate;dihydrochloride; L-Phenylalanine, N-(3,5-dichloro-2-hydroxy-4-(2-(4-methyl-1-piperazinyl)ethoxy)benzoyl)-, ethyl ester, dihydrochloride
Appearance
Off White solid
Solubility
~25 mg/ml in DMSO
Molecular Formula
C25H33Cl4N3O5
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