Caspase-1 Antibody
Product Category:
Apoptosis Inducers & Inhibitors
Description
JGB1741 is a small molecule inhibitor of SIRT1. The sirtuins (SIRTs) are NAD+-dependent histone deacetylases. The IC₅₀ value of JGB1741 in a cell-free assay is 15 μM. The IC₅₀ for cell proliferation of three cancer cell lines, K562, HepG2 and MDA-MB 231 is 1 μM, 10 μM and 0.5 μM, respectively. JGB1741 causes cytochrome c release, modulation in Bax/Bcl2 ratio and cleavage of PARP.
Product Information
Similar Name
4,5,6,7-tetrahydro-2-[(E)-[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(phenylmethyl)-benzo[b]thiophene-3-carboxamide
Appearance
Crystalline solid
Solubility
0.2 mg/ml in in DMSO, ~0.14 mg/ml in DMF
Shipping Conditions
Gel Pack
Molecular Formula
C27H24N2O2S
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