Caspase-1 Antibody
Product Category:
Apoptosis Inducers & Inhibitors
Description
Importazole is a 2,4-diaminoquinazoline that inhibits the function of transport receptor importin-β, likely by altering its interaction with RanGTP. Importazole prevents nuclear import of GFP-tagged nuclear factor of activated T cells (NFAT-GFP) in HEK293 cells with an IC₅₀ of 15 μM, which is reversible upon importazole washout. Importazole inhibits nuclear import of topoisomerase IIβ binding protein 1 (TopBP1) in Xenopus egg extracts and NF-κB in multiple myeloma cells. It induces apoptosis and inhibits growth of multiple myeloma cell lines with IC₅₀ values of 4.4 μM and 4.8 μM, respectively. It also induces defects in astral MT dynamics and misoriented spindles.
Product Information
Similar Name
N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine; IPZ
Solubility
~5 mg/ml in Ethanol, ~30 mg/ml in DMSO and DMF
Molecular Formula
C20H22N4
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