Caspase-1 Antibody
Product Category:
Apoptosis Inducers & Inhibitors
Description
DMXAA acts as a tumor vascular disrupting agent, inducing apoptosis in tumor vascular endothelium resulting in necrosis at the tumor core. It potently activates the TANK-binding kinase 1-interferon regulatory factor 3 signaling pathway in leukocytes, inducing type-I-interferon production. In addition, DMXAA significantly inhibits several kinases in endothelial cells, including the vascular endothelial growth factor (VEGF) receptors VEGFR1 and VEGFR2 (IC₅₀ = 119 and 11 µM, respectively). Recent studies have shown that DMXAA is a competitive agonist ligand for mouse.
Product Information
Molecular Formula
C17H14O4
Shipping Conditions
Gel Pack
Similar Name
2-(5,6-dimethyl-9-oxoxanthen-4-yl)acetic acid; Vadimezan; ASA404
Solubility
DMSO (>10 mg/ml)
Usage
For Research Use Only! Not For Use in Humans.
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