AT-101

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Caspase-1 Antibody

Product Category:
Apoptosis Inducers & Inhibitors

Description

AT-101 is the R-(-) enantiomer of Gossypol that acts as an inhibitor of the antiapoptotic Bcl proteins (Bcl-2, Bcl-XL, Bcl-W, and Mcl-1) and an inducer of the pro-apoptotic proteins noxa and puma. It induces apoptosis in drug-resistant multiple myeloma cell lines. Apoptosis is activated by the mitochondrial pathway.

Product Information

Product Number
CDAP-054
Product Name
AT-101
Appearance
Light brown solid
cas
90141-22-3
Molecular Formula
C30H30O8
Molecular Weight
518.56
Purity
≥98% by TLC
Shipping Conditions
Gel Pack
Similar Name
(-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dim­ethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8­,8'-dicarboxaldehyde; (R)-Gossypol
Solubility
DMSO (~50 mg/ml) or EtOH (~50 mg/ml)
Storage Conditions
-20 ̊C
Usage
For Research Use Only! Not For Use in Humans.

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