Caspase-1 Antibody
Product Category:
Apoptosis Inducers & Inhibitors
Description
Apoptosis activator 2 is a cell-permeable apoptosis activator that promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC₅₀ > 40 μM).
Product Information
Product Name
Apoptosis activator 2
Similar Name
1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione
Solubility
DMSO (~ 30 mg/ml)
Shipping Conditions
Gel Pack
Molecular Formula
C15H9Cl2NO2
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