Caspase-1 Antibody
Product Category:
Autophagy Antibodies
Description
Autophagy, the process of bulk degradation of cellular proteins throμgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) throμgh phosphorylation of autophagy protein APG1. ATG12, another member of the autophagy protein family, forms a conjμgate with ATG5; this conjμgate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjμgate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist.
Product Information
Product Name
APG12/ATG12 Antibody
Similar Name
APG12 , APG12L , ATG12 , HAPG12
Storage Conditions
-20 °C
USAGE
For Research Use Only! Not For Use in Humans.
Appearance
Colorless liquid
Shipping Conditions
Gel Pack
Species Reactivity
Human, mouse, rat
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